|
KMID : 1039320220220020136
|
|
Journal of Liver Cancer
2022 Volume.22 No. 2 p.136 ~ p.145
|
|
|
Stereotactic body radiation therapy for elderly patients with small hepatocellular carcinoma: a retrospective observational study
|
|
Jang Jeong-Yun
Jung Jin-Hong
Lee Dan-Bi
Shim Ju-Hyun
Kim Kang-Mo
Lim Young-Suk
Lee Han-Chu
Park Jin-Hong
Yoon Sang-Min
|
|
|
Abstract
|
|
|
Background/Aim: We aimed to investigate the efficacy and safety of stereotactic body radiation therapy (SBRT) in elderly patients with small hepatocellular carcinomas (HCC).
Methods: Eighty-three patients (89 lesions) with HCC who underwent SBRT between January 2012 and December 2018 were reviewed in this retrospective observational study. The key inclusion criteria were as follows: 1) age ≥75 years, 2) contraindications for hepatic resection or percutaneous ablative therapies, 3) no macroscopic vascular invasion, and 4) no extrahepatic metastasis.
Results: The patients were 75-90 years of age, and 49 (59.0%) of them were male. Most patients (94.0%) had an Eastern Cooperative Oncology Group performance status of 0 or 1. Seventy-four patients (89.2%) had Child-Pugh class A hepatic function before SBRT. The median tumor size was 1.6 cm (range, 0.7-3.5). The overall median follow-up period was 34.8 months (range, 7.3-99.3). The 5-year local tumor control rate was 90.1%. The 3-year and 5-year overall survival rate was 57.1% and 40.7%, respectively. Acute toxicity grade ≥3 was observed in three patients (3.6%) with elevated serum hepatic enzymes; however, no patient experienced a worsening of the Child-Pugh score to ≥2 after SBRT. None of the patients developed late toxicity (grade ≥3).
Conclusions: SBRT is a safe treatment option with a high local control rate in elderly patients with small HCC who are not eligible for other curative treatments.
|
|
|
KEYWORD
|
|
|
Carcinoma, hepatocellular, Radiotherapy, stereotactic body, Elderly, Survival
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|